Regenerating reptile retinas: a comparative approach to restoring retinal ganglion cell function
نویسندگان
چکیده
منابع مشابه
Efficient estimation of retinal ganglion cell number: a stereological approach.
Retinal ganglion cells (RGCs) are the only output neurons of the retina, and their degeneration after damage to the optic nerve or in glaucoma is a well established system for studying apoptosis in the central nervous system. Frequently used procedures for assessing RGC number in retinal flat mounts suffer from two problems: RGC densities are not uniform across retinal flat mounts, and density ...
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Retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are blinding diseases caused by the degeneration of rods and cones, leaving the remainder of the visual system unable to respond to light. Here, we report a chemical photoswitch named DENAQ that restores retinal responses to white light of intensity similar to ordinary daylight. A single intraocular injection of DENAQ photosen...
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1.1 Topographic and cellular organization of the retina The retina is the thin (0.2 mm) lining of the back of the eye that gathers light focused on it by the cornea and lens. The retina has a complex laminar organization; cells are organized into layers (Fig. 1). These layers are named by reference to the middle of the eyeball; the innermost layers are located nearest the vitreous chamber, wher...
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Retinal ganglion cells (RGCs), the sole output cells of the retina, are a heterogeneous population of neurons that project axons to visual targets in the brain. Like most CNS neurons, RGCs are considered incapable of mounting long distance axon regeneration. Using immunolabeling-enabled 3D imaging of solvent-cleared organs (iDISCO) in transgenic mice, we tracked the entire paths of individual R...
متن کاملCharacteristics of growth-associated polypeptides in regenerating toad retinal ganglion cell axons.
We report here certain properties of three polypeptides that are rapidly transported in greatly increased amounts during the regeneration of toad optic nerves. All three of these growth-associated polypeptides (GAPs) are associated with a membrane(s) with a buoyant density similar to the plasma membrane. Since none of these GAPs are solubilized substantially by washing the membranes in either l...
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ژورنال
عنوان ژورنال: Eye
سال: 2016
ISSN: 0950-222X,1476-5454
DOI: 10.1038/eye.2016.224